Birçok sistemi tutan, özellikle hemodinamik değişikliklere yol açarak şok, organ fonksiyon bozukluğu ve organ yetmezliğine giden sepsis hakkında özellikle son yirmi yılda pek çok çalışma yapılmıştır.

Sepsis, günümüzde halen yüksek mortalite ile seyreden tedavisi güç bir klinik tablodur. Bu olaylar, immün hücreler veya hasar görmüş endotel hücrelerinden salınan proinflamatuvar sitokinler, prokoagülanlar ve adezyon molekülleri yoluyla sistemik enflamatuvar yanıt sendromu veya sepsis bulguları ile ortaya çıkar. Sepsis, mikrobiyal maruziyet sonrasında enflamasyon ve koagülasyonun birlikte aktive olmasıyla karakterize komleks bir sendromdur. This review summarizes the sepsis pathophysiology, current treatment protocols, and new approaches. Various therapeutic agents have been used in addition to antibiotherapy, but no satisfactory results have been obtained. In the last decade, the sepsis physiopathology has been elucidated.

In sepsis, increasing antibiotic resistance and medicine-resistant hemodynamic changes have resulted in further research on new treatment modalities in addition to classical treatments. In the last two decades in particular, many studies have been conducted on sepsis that cause shock, multiorgan dysfunction, and organ failure by especially leading to hemodynamic changes. Today, sepsis is a severe multisystem disease with difficult treatments for its manifestations and high mortality rates. These events manifest as systemic inflammatory response syndrome or sepsis symptoms through the release of proinflammatory cytokines, procoagulants, and adhesion molecules from immune cells and/or damaged endothelium. Sepsis is a complex condition characterized by the simultaneous activation of inflammation and coagulation in response to microbial insult.

Does septic system shock treatment work